Scientific Publications

Wu, Q; Crews, M.; Draskovic, M.; Sohn, J.; Johnson, T. A.; Tenney, K.; Valeriote, F.A.; Yao, X.; Bjeldanes, L.F.; Crews, P.

Azonazine, A Novel Dipeptide from a Hawaiian Marine Sediment-Derived Fungus, Aspergillus ochraceopetaliformis.

Organic letters, 2010, 12, 4458-4461. [PDF]

Morgan, B.J.;  Mahdi, F.; Liu, Y.;  Coothankandaswamy, V.;  Jekabsons, M. B.; Johnson, T. A.; Sashidhara, K.V.; Crews, P.; Nagle, D. G.;  Zhou, Y.              

The Marine Sponge Metabolite Mycothiazole: A Novel Prototype Mitochondria Complex I Inhibitor
Bioorganic and Medicinal Chemistry, 2010, 18, 5988-5994.   [PDF]

Crews, P.; Amagata, T.; Johnson, T. A.; Tenney, K.; Mooberry, S. L.; Valeriote, F. A.

Latrunculol Derivatives From Sea Sponges.

PATENT PCT Int. Appl. 2010, 32 pp. WO 2010014240   A2 20100204

Johnson, T. A.; Morgan, M.; Aratow, N.; Estee, S. A.; Sashidhara, K. V.; Loveridge, S.; Segraves, N.L.; Crews, P. 

Assessing Pressurized Solvent Extraction for the High Throughput Profiling of Marine-Sponge Derived Natural Products

Journal of Natural Products, 2010, 73, 359–364.     [PDF] [S.I.]

Shaw, J.; Valeriote, F. A.; Meida, J.; Johnson, T. A.; Amagata, T.; Tenney, K. and Crews, P.

Development and Validation of a Rapid Method for the Detection of Latrunculol A in Plasma

Analytical & Bioanalytical Chemistry, 2010, 396, 1741-1744.   [PDF]

Johnson, T. A.; Amagata, T.; Sashidhara, K. V.; Oliver, A. G.;  Tenney, K.; Matainaho, T.;  Kean-Hooi Ang, K.; McKerrow, J. H; Crews, P. 

A New Sesquiterpene Class, the Aignopsanes from Selected Chemotypes of the Sponge Cacospongia mycofijiensis

Organic letters, 2009, 11, 1975-1978.   [PDF] [S.I.]

Jessup, D.A.; Miller, M.A.; Ryan, J.P.; Nevins, H. M.; Kerkering, H. A.; Mekebri, A.; Crane, D. B.; Johnson, T. A.; Kudela, R. M.

Mass Stranding of Marine Birds Caused by a Surfactant-Producing Red Tide

PLoS One, 2009, 4 (2): e4550.    [PDF]  

Johnson, T. A.; Amagata, T.; Oliver, A. G.; Tenney, K.; Valeriote, F. A.; Crews, P.

The Unexpected Isolation of CTP-431, a Novel Cytotoxic Thiopyrone from the Sponge Cacospongia mycofijiensis

Journal of Organic Chemistry, 2008 73, 7255-7259.     [PDF] [S.I.]

Amagata, T; Johnson, T. A.; Cichewicz, R. H.; Tenney, K.; Mooberry, S. L.; Valeriote, F. A.; Crews, P. 

Interrogating the Bioactive Pharmacophore of the Latrunculin Chemotype by Investigating the Metabolites of Two Taxonomically Unrelated Sponges.

Journal of Medicinal Chemistry, 2008, 51, 7234-7242.     [PDF] [S.I.]

Litaker, R. W.; LeEberhardt, B.; Wekell, J. C.; Trainer, V. L.; Kudela, R. M.; Roberts, A.; Hertz, C.; Johnson, T. A.; Frankfurter, G.; Smith, J. G.; Schnetzer, A.; Hardison, R.; Tester, P.

Rapid Enzyme-liked Immunosorbent Assay for Detection of the Algal Toxin Domoic Acid

Journal of Shellfish Research, 2008, 27, 1301-1310.     [PDF]

Johnson, T. A.; Tenney, K.; Cichewicz, R. H.; Morinaka, B.; White, K. N.; Amagata, T.; Subramanian, B.; Media, J.; Mooberry, S. L.; Valeriote, F. A; Crews, P.

Sponge-Derived Fijianolide Polyketide Class: Further Evaluation of Their Structural and Cytoxicity Properties

Journal of Medicinal Chemistry, 2007, 50, 3795-3803.    [PDF]  [S.I.]  

Deschamps, J. D.; Gautschi, J. T.; Whitman, S.; Johnson, T. A.; Gassner, N. C.; Crews, P.; Holman, T. H. 

Discovery of Platelet-type 12-Human Lipoxygenase Selective Inhibitors by High-throughput Screening of Structurally Diverse Libraries.

Bioorganic & Medicinal Chemistry, 2007, 15, 6900-6908.     [PDF]

Sonnenschein, R. N.; Johnson, T. A.; Tenney, K.; Valeriote, F.; Crews, P. 

A Reassignment of (-)-Mycothiazole and the Isolation of a Related Diol. 

Journal of Natural Products, 2006, 6, 145- 147.     [PDF] [S.I.]  

Segraves, E. N.; Shah, R. R.; Segraves, N. L.; Johnson, T. A.; Whitman, S.; Sui, J. K.; Kenyon, V. A.; Cichewicz, R. H.; Crews, P.; Holman, T. 

Probing the Activity of Simple and Complex Brominated Aryl Compounds against 15-Soybean, 15-Human, and 12-Human Lipoxygenase.

Journal of Medicinal Chemistry, 2004, 47, 4060-4065.    [PDF] [S.I.]  

Amagata, T.; Whitman, S.; Johnson, T. A.; Stessman, C. C.; Loo, C. P.; Lobkovsky, E.; Clardy, J.; Crews, P.; Holman, T.; 

Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-Human, 15-Human, and 15-Soybean Lipoxygenases.

Journal of Natural Products, 2003, 66, 230-235.     [PDF] [S.I.]  

Seagraves, N. L.; Lopez, S.; Johnson, T. A.; Said, S. A.; Fu, X.; Schmitz, F. J.; Pietraszkiewicz, H.; Valeriote, F. A.; Crews, P.

Structures and Cytotoxicities of Fascaplysin and Related Alkaloids from Two Marine Phyla^__Fascaplysinopsis Sponges and Didemnum Tunicates. 

Tetrahedron Letters, 2003, 44, 3471-3475.     [PDF]

Thale, Z.; Johnson, T. A.; Tenney, K.; Wenzel, P. J.; Lobkvovsky, E.; Clardy, J.; Media, J.; Pietraszkiewicz, H.; Valeriote, F. A.; Crews, P.

Structures and Cytotoxic Properties of Sponge-Derived Bisannulated Acridines.

Journal of Organic Chemistry, 2002, 67, 9384-9391.      [PDF] [S.I.]